Postsynaptic current analysis of a model prefrontal cortical circuit for multi-target spatial working memory
نویسندگان
چکیده
The two-layer prefrontal cortical circuit model proposed by Tanaka and Yoshida (Neurocomputing 38–40 (2001) 957) produces cue-period activity in one layer and delay-period activity in the other layer. We have extended this model to have three layers and analyzed the spatio-temporal structures of the postsynaptic currents of neurons representing multiple target locations as well as single target locations. The computer simulation shows the three-dimensional spatio-temporal pro3les of the excitatory and inhibitory postsynaptic currents of the pyramidal cells representing multiple target locations in the delay period. c © 2002 Elsevier Science B.V. All rights reserved.
منابع مشابه
Enhancement of Visuospatial Working Memory by Transcranial Direct Current Stimulation (tDCS) on Prefrontal and Parietal Cortices
Objective: Previous studies have reported dorsolateral prefrontal cortex (DLPFC) and posterior parietal (PPC) activation during the performance of spatial working memory (SWM), so we decided to investigate the comparison of Transcranial Direct current stimulation (tDCS) effect between these two areas. Methods: Fifty-four healthy right-handed students (27 female, 27 male; age= 24.3±.2 years) w...
متن کاملEffects of left prefrontal transcranial direct current stimulation on the acquisition of contextual and cued fear memory
Objective(s): Behavioral and neuroimaging studies have shown that transcranial direct current stimulation, as a non-invasive neuromodulatory technique, beyond regional effects can modify functionally interconnected remote cortical and subcortical areas. In this study, we hypothesized that the induced changes in cortical excitability following the application of cathodal or anodal tDCS over the ...
متن کاملEffects of systemic and intra-prefrontal cortex administrations of ethanol on spatial working memory in male rats
Introduction: Ethanol can induce a wide spectrum of neurophysiological effects via interaction with multiple neurotransmitter systems and disruption of the balances between inhibitory and excitatory neurotransmitters. Prefrontal cortex is involved in cognitive process including working memory and is sensitive to ethanol. Present study investigates the effects of intraperitoneal (i.p.) admini...
متن کاملModular Circuitry and Network Dynamics for the Formation of Visuospatial Working Memory in the Primate Prefrontal Cortex
A model of the prefrontal cortical circuit has been constructed to investigate the dynamics for working memory processing. The model circuit is multi-layered and consists of a number of circuit modules or columns, each of which has local, excitatory and inhibitory connections as well as feedback connections. The columns interact with each other via the longrange horizontal connections. Besides ...
متن کاملCortico-thalamocortical operations of multi-target spatial working memory
Representation and manipulation of multiple target locations would be important aspects of spatial working memory [Tanaka 2002a, b]. It is, however, unknown how such processes are performed in the prefrontal cortical, corticocortical, and cortico-subcortical circuits. We here propose a model of the prefrontal cortical and cortico-thalamocortical circuits that represent and manipulate multiple t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Neurocomputing
دوره 44-46 شماره
صفحات -
تاریخ انتشار 2002